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Dr Sarah Maddocks
Associate Lecturer

Cardiff School of Health Sciences
University of Wales Institute, Cardiff
Western Avenue
Cardiff
CF5 2YB
Wales
Email: smaddocks@uwic.ac.uk

Teaching
Medical microbiology and fundamental microbiology to biomedical scientists

Research Profile

Career details
2007-2009 Post Doctoral Research Assistant, Dept of Oral and Dental Microbiology, University of Bristol
2005-2007 Post Doctoral Research Assistant, Dept of Biomedical Sciences, Defence Science and Technology Laboratories (DSTL), Porton Down
2006 PhD, University of Reading
2002 BSc, Nottingham University

Research Interests
Molecular studies of bacterial pathogenicity, virulence and host-pathogen interactions. Initial work investigated the ferrous iron acquisition system in E. coli as part of an iron-mediated virulence regulon. This led to an interest in transcriptional regulation of virulence factors, and the characterisation of LysR-type transcriptional regulators in the zoonotic pathogen Franscisella tularensis, with the view to generating a live attenuated vaccine strain. The contribution of host-pathogen interaction to virulence of human pathogens focussed on characterising the surface protein AgI/II of Streptococcus pyogenes and its association with human innate immunity glycoprotein gp340, and factors affecting its expression.

Selected publications
1. Maddocks, S. E. and Oyston, P. C. F. (2008) Structure and function of the LysR-type transcriptional regulator (LTTR) family proteins.  Microbiology 154: 3609-3623
2. Cartron, M. L., Maddocks, S., Gillingham, P., Craven, C. and Andrews, S. C. (2006) Feo: transport of ferrous iron into bacteria. Biometals 19: 143-157