Dr Keith Morris 
BSc(Hons), BA, MSc, PhD FIBMS, C.Sci.

Contact Details
Cardiff School of Health Sciences
University of Wales Institute, Cardiff (UWIC)
Western Avenue, Cardiff CF5 2YB, UK

Room T216
Tel: + 44 (0) 29 2041 6826
Fax: + 44 (0) 29 2041 6982
Email.kmorris@uwic.ac.uk

Present Appointments
Since 2003 Reader in Biomedical Sciences, Cardiff School of Health Sciences, University of Wales Institute, Cardiff, UK

Career details
1995-2003        Senior Lecturer in Biomedical Sciences and Statistics, School of Applied Sciences , UWIC
1985-1994        Chief/Senior Chief Biomedical Scientist, Princess of Wales Hospital
1976-1985        Senior Biomedical Scientist-various hospitals including Rhyiad Military Hospital Saudi Arabia
2000                PhD, University of Wales UWIC/ UWCM
1988                MSc Chemical Analysis, Bristol UWE
1985                BA Maths/Stats  
1976                BSc Chemistry/Biology. University of Wales

Research Interests
After studying Chemistry/Biology at UWIST in Cardiff, I moved to the NHS at worked as a State Registered Biomedical Scientists for nearly 19 years. My main role was in diagnostic and clinical haematology. It was during this time that I acquired my B.A. in Statistics/Mathematics and M.Sc. in Analytical Chemistry. I left the NHS when I was told that since they were paying me so much money, I had to have a greater managerial, rather than a scientific role. I moved to UWIC in 1995, and acquired a PhD supervised by Professor Ken Jones in the regulation of inflammation by saturated lipids. I remain very interested in the inflammatory response and its regulation by both lipids and exercise mediated through an important group of nuclear receptors the PPARs. I attempt to apply my research to a number of diseases, but I am particularly interested in type 2 Diabetes (T2D), which is a major public health problem due to its inflammatory nature.  This inflammation is a major cause of cardiovascular and inflammatory disease. I have published a number of papers in this area and supervise a number of PhDs in the regulation of inflammation and lipid homeostasis in T2D. I have also discovered that being a statistician is a surprisingly easy way to make new friends and collaborators. Consequently I have also published in statistical methods as applied to Clinical Studies and have consulted and designed several clinical trials. I have been a consultant to The World Health Organization on three separate occasions in Nepal and Sri Lanka, where I have advised these governments and the WHO on advanced laboratory methods of analysis for a number of diseases.

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Selected Publications
Morris K,  TONKS  AJ, TONKS, A, , AHLUWALIA MK, THOMAS AW, JONES, KP,  JACKSON, SK (2008)  DPPC regulates COX-2 expression in monocytes via phosphorylation of CREB Biochemical Biophysical Research Communications (in Press)

Pinder, AG, Rogers, SC, Morris, K, James PE (2008)  Haemoglobin saturation controls the red blood cell mediated hypoxic vasorelaxation. Adv. Exp. Biol. (In Press)

Khanolkar M, Morris K, Thomas AW, Evans M (2007) Rosiglitazone  produces a greater reduction  in circulating platelet activity  compared with gliclazide in patients with type2 diabetes mellitus – an effect probably mediated by direct platelet PPAR gamma activation. Atherosclerosis (in press)

Butcher, L., Backx, K., Roberts, A., Thomas, A., Webb, R., and Morris, K. (2008) Low-intensity exercise regulates LDL oxidation, and expression of genes responsible for lipoprotein clearance and reverse cholesterol transport, in previously sedentary adults. J.Med Sci. Ex. Sp. (in press).

Bolton, CE., Evans, M., Ionescu, A., Edwards SM., Morris RH, Luzio S, Owens D.,  Shale D. (2007) Insulin resistance and inflammation - A further systemic complication of COPD COPD. 4:121-6.Anderson, RA, Evans LM, Ellis, GR, Khan, N., Morris, K. et al (2006) Prolonged deterioration of endothelial dysfunction in response to postprandial lipaemia is attenuated by vitamin C in Type 2 diabetes Diabetic Medicine, 23 ,  258-264

Roberts, A W and Morris K (2005) Hyperlipidaemia and cardiovascular disease. Curr Opin Lipidol. 16(2):253-5.

Anderson, RA, Ellis, GR, Evans LM, Morris, K. (2005) Platelet Nitrate responsiveness in fasting and postprandial diabetes. Diab. and Vasc. Dis. Res. (2)

Tonks A., Parton J,.Tonks A J,. Morris R H. K, et al (2005) The surfactant phospholipid, DPPC, down regulates monocyte monocyte respiratory burst via modulation of PKC. Am J Physiol Lung Cell  Mol Physiol 288:L1070-80.

Evans M, Anderson RA, Smith JC, Khan N, Graham JM, Thomas AW, Morris K, Frenneaux MP, Rees A. (2003) Effects of insulin lispro and chronic vitamin C therapy on postprandial lipaemia, oxidative stress and endothelial function in patients with type 2 diabetes mellitus Eur. J. Clin. Invest. 33:231-8.

Ahluwalia, M., Evans, L., Morris, K.,, Davies, S., Rees, A. and Thomas, A. (2002) The Pro12Ala mutation of PPAR-gamma receptor gene is associated with lower fasting plasma glucose and elevated total and non-HDL cholesterol levels in obese patients with type 2 diabetes. Diab. Ob, Met  4: 376-8.

Anderson, R.A., Evans, M.L., Ellis, G.R., Graham, J, Morris, K, Jackson, S.K, Lewis, M.J., Rees, A., Frenneaux, M.P.2001) The relationships between post-prandial lipaemia, endothelial function and oxidative stress in healthy individuals and patients with type 2 diabetes.  Atherosclerosis 154: 75-83.

Ellis,G.R., Anderson, R.A., Lang, D., Morris, R.H.K., Morris-Thurgood, J., McDowell, I.F. Lewis M., Frenneaux, M.P (2000) Neutrophil Superoxide Anion Generating Capacity, Endothelial Function and Oxidative Stress in Chronic Heart Failure; Effects of Acute and Chronic Vitamin C Therapy. JACC. 36:1474-1482

Evans L.M., Anderson, R.A., Graham, J., Ellis, G., Morris, K. Davies, S., Jackson, S.K. and Rees, A. (2000) Ciprofibrate therapy improves endothelial function and reduces post prandial lipaemia and oxidative stress in type 2 diabetes mellitus. Circulation 101: 1773-1779.