Dr Lee Butcher 

Dr Lee Butcher
Postdoctoral Research Scientist

Cardiff School of Health Sciences
Cardiff Metropolitan University
Western Avenue
Cardiff
CF5 2YB
UK
Tel: + 44 (0) 29 2020 1171
Fax: + 44 (0) 29 2041 6982
Email: lbutcher@cardiffmet.ac.uk

Present Appointments
Since 2010: Postdoctoral Research Scientist, Cardiff School of Health Sciences, Cardiff Metropolitan University, Cardiff, UK

Career Details
2009-2010: Research Assistant (MRC Grant), Cardiff School of Health Sciences, Cardiff Metropolitan University, Cardiff, UK

2005-2009: PhD, Cardiff School of Health Sciences, University of Wales Institute, Cardiff (UWIC), Cardiff, UK

2002-2005: BSc (Hons), Cardiff School of Health Sciences, University of Wales Institute, Cardiff (UWIC), Cardiff, UK

Research Interests
My current research involves exploring the transcriptional regulation of megakaryopoiesis using cell culture model systems. I am also interested in the effects of lifestyle choices on biomarkers of cellular ageing, in particular telomere length. Some of my past work has also involved investigating the role of physical activity in modulating molecular signalling events associated with cardiovascular disease, diabetes and obesity.

Publications
1. Thomas, A.W., Davies, N.A., Moir, H., Watkeys, L., Ruffino, J.S., Isa, S.A., Butcher, L.R., Hughes, M.G., Morris, K. and Webb, R. (2011) Exercise-associated generation of PPARγ ligands activates PPARγ signalling events and upregulates genes related to lipid metabolism. J. Appl. Physiol. Epub ahead of print Dec 15 PMID 22174394

2. Brydon, L., Lin, J., Butcher, L., Hamer, M., Erusalimsky, J.D., Blackburn, E.H. and Steptoe, A. (2011) Hostility and cellular aging in men from the Whitehall II cohort. Biol. Psychiatry. Epub ahead of print Oct 3 PMID 21974787

3. Steptoe, A., Hamer, M., Butcher, L., Lin, J., Brydon, L., Kivimaki, M., Marmot, M., Blackburn, E. and Erusalimsky, J.D. (2011) Educational attainment but not current socioeconomic status is associated with leukocyte telomere length. Brain Behav. Immun. 25, 1292-1298

4. Yakeu, G., Butcher, L., Webb, R., Roberts, A., Thomas, A.W., Backx, K., James, P.E. and Morris, K. (2010) Low-intensity exercise enhances expression of markers of alternative activation in circulating leukocytes: roles of PPARγ and Th2 Cytokines. Atherosclerosis. 212, 668-673

5. Ahluwalia, M., Donovan, H., Singh, N., Butcher, L. and Erusalimsky, J.D. (2010) Anagrelide represses GATA-1 and FOG-1 expression without interfering with thrombopoietin receptor signal transduction. J. Thromb. Haemost. 8, 2252-2261

6. Moir, H., Hughes, M.G., Potter, S., Sims, C., Butcher, L.R., Davies, N.A., Verheggen, J., Jones, K.P., Thomas, A.W. and Webb, R. (2010) Exercise-induced Immunosuppression: The Roles of Reactive Oxygen Species and 5'AMP-activated Protein Kinase (AMPK) Dephosphorylation within Immune Cells. J. Appl. Physiol. 108, 1284-1292

7. Butcher, L., Backx, K., Webb, R., Thomas, A., Roberts, A. and Morris, K. (2009) Low-intensity exercise regulates PPAR-γ activity: a molecular rationale for diabetes prevention? J. Diabetes. 1, A71-72

8. Butcher, L.R., Thomas, A., Backx, K., Roberts, A., Webb, R. and Morris, K. (2008) Walking, PPARs And Their Regulated Genes. Med. Sci. Sports. Exerc. 40, S58

9. Butcher, L.R., Thomas, A., Backx, K., Roberts, A., Webb, R. and Morris, K. (2008) Low-intensity exercise exerts beneficial effects on plasma lipids via PPARγ. Med. Sci. Sports. Exerc. 40, 1263-1270

10. Moir, H., Butcher, L., Jones, K.P., Hughes, M.G., Neale, H., Jia, H., Al-Ismaily, Z. and Webb, R. (2008) AMPK Inactivation in Mononuclear Cells: A Potential Intracellular Mechanism For Exercise-Induced Immunosuppression. Appl. Physiol. Nutr. Metab. 33, 75-85